Previous GBS-affected infant

There is not a large body of research to guide management when a previous baby was affected by GBS disease.

The next infant is probably at increased risk of the infection, but it is not currently possible to quantify the exact level of risk. The incidence of recurrent GBS disease may be due to low levels of maternal anti-GBS antibodies.

	Intrapartum antibiotic prophylaxis should be offered to women with a previous baby with neonatal GBS disease

Penicillin 3g IV as soon as possible after the onset of labour
followed by
Penicillin 1.5g IV four-hourly until delivery
Or, in the case of penicillin sensitivity,
Clindamycin 900mg IV eight-hourly